Humanin
Mitochondria-derived peptide discovered in Alzheimer's research; human administration has not been studied.
Not FDA-approved. Research only. This page describes research and public discussion; it is not a recommendation to use.
Overview
Humanin was discovered in 2001 as a neuroprotective factor in surviving brain tissue of Alzheimer's patients. Circulating levels decline with age and are higher in children of centenarians.
Mechanism of action
Binds FPRL1 and a CNTFR/WSX-1/gp130 receptor complex; inhibits BAX-mediated apoptosis.
Benefits & evidence ratings
Dosing
Doses show what has been studied or discussed — not guidance. Always follow your prescriber.
| Source | Dose | Frequency | Duration | Route |
|---|---|---|---|---|
Clinically studied C Preliminary research | None | — | — | — |
Clinical trials & studies
- Review2017Humanin: a mitochondrial signaling peptide (Review)
Preclinical overview.
Safety
Side effects
- Unknown
Contraindications
- Pregnancy
Interactions
- Unknown
Long-term safety
Unknown.
Regulatory status
Unapproved / research
Research only.
FAQ
Commonly discussed alongside
Listing a combination does not mean it has been studied or is safe.