Epitalon
Epithalon · Ala-Glu-Asp-Gly
Synthetic tetrapeptide from Russian gerontology research; claims rest on a small group's studies.
Not FDA-approved. Not approved. FDA Category 2 bulk listing. This page describes research and public discussion; it is not a recommendation to use.
Overview
Epitalon is based on epithalamin, a pineal extract. Russian studies by Khavinson and colleagues report telomerase activation in cell culture, lifespan extension in rodents, and benefits in elderly cohorts, but independent replication is lacking.
Mechanism of action
Proposed telomerase induction and regulation of melatonin secretion.
Benefits & evidence ratings
Dosing
Doses show what has been studied or discussed — not guidance. Always follow your prescriber.
| Source | Dose | Frequency | Duration | Route |
|---|---|---|---|---|
Russian elderly-cohort studies (epithalamin) C Preliminary research | Various | Courses | 10–20 days | IM |
Online protocols D Anecdotal / community | 5–10 mg | Daily | 10–20 days, 1–2× per year | Subcutaneous |
Clinical trials & studies
- In vitro2003Epithalon peptide induces telomerase activity (Bull Exp Biol Med)
Telomerase in human fibroblast culture.
Safety
Side effects
- Unknown; few reports
Contraindications
- Cancer history (telomerase concern)
- Pregnancy
Interactions
- Unknown
Long-term safety
Unknown.
Regulatory status
Unapproved / research
Not approved. FDA Category 2 bulk listing.