DSIP
Delta Sleep-Inducing Peptide
Nonapeptide isolated in 1977 from rabbits; small human trials show inconsistent effects on sleep.
Not FDA-approved. Not approved. This page describes research and public discussion; it is not a recommendation to use.
Overview
DSIP was named for inducing delta-wave sleep in rabbits. Small 1980s human studies in insomnia had mixed results, and its endogenous receptor and gene have never been identified.
Mechanism of action
Unclear. Proposed modulation of GABAergic, glutamatergic and stress-hormone pathways.
Benefits & evidence ratings
Dosing
Doses show what has been studied or discussed — not guidance. Always follow your prescriber.
| Source | Dose | Frequency | Duration | Route |
|---|---|---|---|---|
1980s insomnia trials C Preliminary research | 25 nmol/kg | Evening | Several nights | IV |
Online protocols D Anecdotal / community | 100–300 mcg | Before bed | Short courses | Subcutaneous / nasal |
Clinical trials & studies
- RCT1980sDSIP in chronic insomnia: double-blind study
Modest or no improvement vs placebo.
Safety
Side effects
- Headache, nausea (reported)
- Morning grogginess
Contraindications
- Pregnancy
Interactions
- CNS depressants (theoretical)
Long-term safety
Unknown.
Regulatory status
Unapproved / research
Not approved.
FAQ
Commonly discussed alongside
Listing a combination does not mean it has been studied or is safe.