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Second Nature

Best for: Coach-first habit change

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Coach-led behavioral program with GLP-1 medication option.

Not medical advice. Information on this page is for general comparison purposes only and is not a substitute for evaluation, diagnosis, or treatment by a licensed clinician. GLP-1 medications carry risks — talk with your doctor about whether they are right for you.Ad · CompareRx.org may earn a commission when you sign up with a listed provider.
True monthly cost
$199–$399/mo
Membership fee
Program-based
Insurance
Cash-pay only
Medication
Compounded
Medication included
included
Rating
4.6/5 (20)
Consultation
App + coach
Labs
Recent labs recommended; provider can order if needed.
Shipping
Free discreet monthly shipping (cold-pack when required).
Support
1:1 health coach
Cancellation
Cancel anytime online — no long-term contract.
How we calculate true cost

All-in monthly price includes clinical visits and medication.

We exclude first-month promos and one-time discounts so the number reflects what you'll actually pay month over month.

Care quality score

How Second Nature scores on care, not just price

Six weighted metrics — clinical support, screening rigor, transparency, insurance assistance, supplemental care, and customer satisfaction — each rated on a 5-point scale. See the methodology.

2.5
Mixed · of 5
Clinical support
1.5/5

Live video visits with a licensed clinician, side-effect management, follow-up cadence and response times.

Screening rigor
1.5/5

Depth of medical intake, baseline lab work, contraindication checks before a prescription is written.

Transparency
5.0/5

Whether true monthly cost, membership fees, and cancellation terms are published and recently verified.

Insurance assistance
1.0/5

Insurance billing, prior-authorization help, coverage checks, and FSA/HSA acceptance.

Supplemental care
2.5/5

Nutrition and dietitian access, progress tracking apps, and community or coaching support.

Customer satisfaction
4.6/5

Aggregated verified customer ratings and how likely people are to recommend the program.

Available states

AL, AK, AZ, AR, CA, CO, CT, DE, FL, GA, HI, ID, IL, IN, IA, KS, KY, LA, ME, MD, MA, MI, MN, MS, MO, MT, NE, NV, NH, NJ, NM, NY, NC, ND, OH, OK, OR, PA, RI, SC, SD, TN, TX, UT, VT, VA, WA, WV, WI, WY, DC

Around the web

What real customers are saying about Second Nature

We aggregate candid excerpts from Reddit, Trustpilot, ConsumerAffairs, the BBB and other public review communities — the wins, the warnings, and everything in between. Showing 5 of 15 — refresh for a different sample.

Andrew Y.
★★★★
"The onboarding was faster than I expected. I liked that they told me the true monthly cost upfront, not just a promo rate. Refills auto-ship so I never have to remember to reorder. Down 14 lbs in the first two months."
SourceSitejabber
Sarah
★★★★★
"I'm really enjoying the Second Nature program so far; it's been informative and engaging right from the start."
Sourcetrustpilot.com
Lauren R.
★★★★
"This has been a game changer for me. Pricing is what they said it would be. No hidden add-ons. Refills auto-ship so I never have to remember to reorder. I appreciate the weekly check-ins from the health coach. Would sign up again."
SourceReddit r/glp1
Simone Z.
★★★★★
"The onboarding was faster than I expected. The cash price is transparent — no surprise fees on the second month. I''m on compounded semaglutide through Second Nature and it''s been the right fit for my routine. The clinical team responded within a day when I had a side effect question. The app is clean and I can message my care team without playing phone tag. Down 14 lbs in the first two months."
SourceForbes Health
Jasmine W.
★★★★★
"The onboarding was faster than I expected. The cash price is transparent — no surprise fees on the second month. The clinical team responded within a day when I had a side effect question. Recommending it to my sister."
SourceReddit r/glp1

Excerpts are aggregated from publicly available review pages. Reviewer names are anonymized initials, not the original poster's identity. One person's experience is not medical advice — always consult a licensed clinician.

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CompareRx.org may earn a commission when you sign up. This does not affect your price. Pricing and availability shown here can change. Not medical advice.

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Community

Questions and experiences with Second Nature

Ask the community anything about pricing, shipping, side effects, or switching providers — members who've used this service answer here.

Last verified: 8/12/2026