Kisspeptin

Kisspeptin-10 / -54

Upstream regulator of GnRH studied for fertility, hypogonadism, and sexual brain processing.

InvestigationalHormones & FertilitySexual Wellness

Not FDA-approved. Investigational; not approved for any indication. This page describes research and public discussion; it is not a recommendation to use.

Overview

Kisspeptin neurons trigger GnRH release and therefore LH, FSH, and sex hormones. Imperial College London trials have used kisspeptin to trigger egg maturation in IVF and to enhance brain responses to sexual cues.

Mechanism of action

Activates KISS1R (GPR54) on GnRH neurons, increasing pulsatile GnRH → LH/FSH secretion.

Benefits & evidence ratings

Triggers oocyte maturation in IVF with low OHSS riskB Human clinical data

Raises LH and testosterone acutely in menB Human clinical data

Enhances brain activity to sexual stimuli (fMRI)B Human clinical data

Dosing

Doses show what has been studied or discussed — not guidance. Always follow your prescriber.

Source	Dose	Frequency	Duration	Route
IVF trigger trial (Kisspeptin-54) B Human clinical data	1.6–12.8 nmol/kg	Single dose	One-time	Subcutaneous
Sexual-function fMRI studies B Human clinical data	1 nmol/kg/h	Infusion	~75 minutes	IV

Clinical trials & studies

Phase 22014
Kisspeptin-54 triggers egg maturation in IVF (J Clin Invest)
Successful oocyte maturation and live births.
Human study2017
Kisspeptin modulates sexual brain processing in men (JCI Insight)
Enhanced limbic responses to erotic stimuli.

Safety

Side effects

Generally well tolerated in short studies
Possible flushing

Contraindications

Hormone-sensitive cancers (theoretical)
Pregnancy

Interactions

GnRH analogues

Long-term safety

Continuous exposure can desensitize the axis (tachyphylaxis).

Regulatory status

Investigational

Investigational; not approved for any indication.

FAQ

Commonly discussed alongside

Enclomiphene

Listing a combination does not mean it has been studied or is safe.